Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while reducing blood glucose and improving lipid levels. Citrullus colocynthis in the germplasm resources information network grin, u. Extraction and characterization of citrullus colocynthis oil. Cucurbitacins from the leaves of citrullus colocynthis l. Citrullus colocynthis fruits are usually recognized for its wide range of medicinal uses as well as pharmaceutical and nutraceutical potential. The present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of extracts and chemicals identified from citrullus colocynthis. Al rabiah botany and microbiology department, faculty of science, king saud university, riyadh, saudi arabia. Citrullus colocynthis an overview sciencedirect topics. Ibhrahim1 department of botany and microbiology, college of science, king saud university. Effects of hydroethanol extract of citrullus colocynthis. Citrullus colocynthis was reported in multiple ethnopharmacologic studies from different part of the world as a traditional remedy for a variety of diseases including gastrointestinal, musculoskeletal, neurological, cardiovascular, and respiratory disorders also, diabetes mellitus is known as the most popular traditional indication of c. Citrullus colocynthis contained carbohydrate, protein, separated amino acid, tannins, saponins. Citrullus colocynthis, cucurbitaceae, indravaruni, bitter apple. Effects of alkaloid rich extract of citrullus colocynthis fruits on artemia salina and human cancerous mcf7 and hepg2 cells aniruddha mukherjee, savita d patil abstract in the present research the anticancer effect of alkaloid rich extract of citrullus colocynthis fruits.
Effects of alkaloid rich extract of citrullus colocynthis. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Several studies on this plant reported and focused on the biological and toxicological profile of fruits pulp. Bitter apple scientific name the scientific name for this plant is citrullus colocynthis. To evaluated the differential effects of ethanol extraction of citrullus colocynthis c. Taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Colocynthis homaccord fda prescribing information, side. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while. All structured data from the file and property namespaces is available under the creative commons cc0 license. Cocyntal activated charcoal, citrullus colocynthis fruit, copper liquid out of scope out of scope for rxnorm and will not receive rxnorm normal forms.
Compound 1 possesses an unprecedented 2,11lactone moiety, while. Effect of the rootknot nematode meloidogyne incognita and the fruit extract of citrullus colocynthis on chlorophyll content a, b and total mgg of fr. Sufficient amount of citrullus colocynthis fruits were prepared and dissolved in 80 methnol and prepared in ointment baseat 80% concentration. The fruit pulp of colocynth has medicinal properties while the seeds have nutritive qualities.
Antioxidant activity of citrullus colocynthis pulp extract in the rbcs of alloxaninduced diabetic rats dallak m, binjaliah i department of physiology, college of medicine, king khalid university, abha, aseer, saudi arabia background. Citrullus colocynthis extracts insecticidal activity pdf abstract. Previous studies in our laboratory showed that citrullus colocynthis pulp seedless extract. The toxic effect of alcoholic extract of citrullus. As already mentioned, that flour enriches and thickens soups as well as other foods. Science and technology, general agricultural chemicals antimitotic agents antineoplastic agents fertilizers research food additives germination liquid chromatography phytochemicals plant. The leaf extract of two cucurbitacious plants citrullus colocynthis and cucurbita. Autecological studies on citrullus colocynthis species in. The fruit pulp of colocynth has medicinal properties while the seeds. Screening of antioxidant potential of methanolic extract.
Citrullus colocynthis is a very droughttolerant medicinal species, closely related to watermelon c. Despite its promise for the food industry, it is the smallscale, subsistence use that most concerns us here. Known hazards the plant contains a number of potentially toxic compounds and can be harmful if used in quantity. Files are available under licenses specified on their description page. Citrullus colocynthis on integrated taxonomic information system.
Citrullus colocynthis fruits were extracted by different solvents nhexane. Colocynth definition of colocynth by the free dictionary. The citrullus colocynthis extract significantly lowered the formation of granuloma tissue in chronic inflammation model. These compounds include elatermidine, glycosides, resin, dihydric alcohol, heltiacontane, citrullin and citrullinic acid. Citrullus colocynthis as the cause of acute rectorrhagia. Screening of antioxidant potential of citrullus colocynthis methanolic extract sudhanshu 1, nidhi rao 1 sandhya mittal 1 and ekta menghani 2 1suresh gyan vihar university, jaipur 2mahatma gandhi institute of applied sciences, jecrc campus, jaipur22. Citrullus colocynthis extracts insecticidal activity pdf. Four ringa secocucurbitane triterpenoids, colocynthenins ad 14, together with seven known cucurbitane triterpenoids 511, were isolated from the fruits of citrullus colocynthis. It was banned by the food and drug administration fda in 1991. Transesterification of citrullus colocynthis thumba oil. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Four patients with colocynth intoxication are presented. Twenty five different accessions of the species were collected.
Citrullus colocynthis is a medicinal plant that has anticancer property mediated by apoptosis. The present study focused on the cytotoxic and genotoxic potency of aqueous leaves extract of this plant. Chemical constituents and pharmacological effects of. Enhancement of callus induction and cucurbitacin content. Germplasm of citrullus colocynthis in the united arab emirates was studied to find variation in it. Department of agriculture agricultural research service. New state records for citrullus, cucumis, and cucurbita cucurbitaceae outside of cultivation in the usa. Pdf the present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of. In the experimental groups a single daily dose of alcoholic extract of citrullus colocynthis 50, 100, 200, 400 gkg was administered intraperitonally. Cphydroxybenzoylglycoflavones from citrullus colocynthis.
The bitter apple is a vinelike plant commonly found in asia and the mediterranean basin. These plants have lemonsized fruits which are known for their medicinal properties. Colocynthenins ad, ringa secocucurbitane triterpenoids. Phenolic compounds and antiradical properties of methanolic extracts of citrullus colocynthis and plantago major in iran afsaneh moslemi mehni 1, fatemeh shahdadi 2 1young researchers and elite club, jiroft branch, islamic azad university, jiroft, iran 2department of.
Cocyntal activated charcoal, citrullus colocynthis. This page was last edited on 24 november 2014, at 11. Enhancement of callus induction and cucurbitacin content in citrullus colocynthis l. Toxic effect of citrullus colocynthis on liver ijpt. Why is dailymed no longer displaying pill images on the search results and drug info pages. Citrullus colocynthis is a folk medicinal plant of saudi arabia. Citrullus colocynthis fruits are usually recognized for its wide received in revised form range. The article also presents some of the functions of the chemicals present and attempt to emphasize and create an awareness of the great potential of citrullus colocynthis as a source of novel. Citrullus colocynthis cct, also known as bitter apple, wild gourd, tumba and wine of sodom, is known for its medicinal value since long. Citrullus colocynthis supplement health benefits, dosage. Fifty rats were randomly divided into five groups 4 experimental and 1 controls. Based on the above findings, the researchers agreed that citrullus colocynthis is suitable for use as an antiinflammatory agent. Report by journal of the alabama academy of science.
Sollmann t 1957 a manual of pharmacology and its applications to. Physiological effects of allelopathic activity of citrullus colocynthis on vicia faba and hordeum vulgare hediat m. It was banned by the food and drug administration in 1991 taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Schrad is a valuable cucurbit plant, widely distributed in the desert areas of the world. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ecd calculations. Bitter apple common names bitter apple trees are also known by a host of common.
This research discussed an analytical study of citrullus colocynthis plants oil, where. Schrader cucurbitaceae family is a fruit commonly known as bitter apple or bitter cucumber, found in sudan, iran and india. The word citrullus is the diminutive of the greek word citrus. Persons familiar with the common watermelon vine need no description of the plant which produces colocynth apples.
The present study was performed to determine the efficacy of citrullus colocynthis on cutaneous leishmaniasis lesion in human. Citrullus colocynthis, also known as bitter cucumber, is a fruitbearing plant sometimes used medicinally. The fruit of citrullus colocynthis has been studied extensively for its wide range of biological. Autecological studies on citrullus colocynthis species in saudi arabia najat a.
There have been reports of death following ingestion of just 112. Watermelon, wild watermelon, egusi melon, west african watermelon, dessert watermelon, cooking melon, fodder melon, preserving melon, citron, melancia portuguese, pasteque french 1,6,8,9 etymology. Citrullus colocynthis, cucurbitacins, cytotoxicity. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. There have been reports of death following ingestion of just. The main clinical feature was acute rectorrhagia preceeded by mucosal diarrhea with tenesmus, which gradually progressed to bloody diarrhea and overt rectorrhagia within 3 to 4 hours. Citrullus colocynthis at encyclopedia of life citrullus colocynthis at national center for biotechnology information. Conventionally citrullus colocynthis fruits are used in antidiabetic treatment in mediterranean countries. However, it is not a legal authority for statutory or regulatory purposes.
459 687 362 259 1638 1211 286 1355 1081 1066 820 755 1419 1231 939 463 1270 513 1207 1369 1210 963 1450 1564 1052 575 165 16 364 733 312 570 56 146 218 1208 844 716 156 101 844 22 621