However, it is not a legal authority for statutory or regulatory purposes. The fruit pulp of colocynth has medicinal properties while the seeds have nutritive qualities. Phenolic compounds and antiradical properties of methanolic extracts of citrullus colocynthis and plantago major in iran afsaneh moslemi mehni 1, fatemeh shahdadi 2 1young researchers and elite club, jiroft branch, islamic azad university, jiroft, iran 2department of. Antioxidant activity of citrullus colocynthis pulp extract in the rbcs of alloxaninduced diabetic rats dallak m, binjaliah i department of physiology, college of medicine, king khalid university, abha, aseer, saudi arabia background. Other side effects include convulsions, paralysis, and death. The word citrullus is the diminutive of the greek word citrus.
Watermelon, wild watermelon, egusi melon, west african watermelon, dessert watermelon, cooking melon, fodder melon, preserving melon, citron, melancia portuguese, pasteque french 1,6,8,9 etymology. Bitter apple scientific name the scientific name for this plant is citrullus colocynthis. Toxic effect of citrullus colocynthis on liver ijpt. Compound 1 possesses an unprecedented 2,11lactone moiety, while. Schrader cucurbitaceae family is a fruit commonly known as bitter apple or bitter cucumber, found in sudan, iran and india. There have been reports of death following ingestion of just 112. The toxic effect of alcoholic extract of citrullus. Citrullus colocynthis is a folk medicinal plant of saudi arabia. Citrullus colocynthis at encyclopedia of life citrullus colocynthis at national center for biotechnology information. Cocyntal activated charcoal, citrullus colocynthis. Sufficient amount of citrullus colocynthis fruits were prepared and dissolved in 80 methnol and prepared in ointment baseat 80% concentration.
Why is dailymed no longer displaying pill images on the search results and drug info pages. In the experimental groups a single daily dose of alcoholic extract of citrullus colocynthis 50, 100, 200, 400 gkg was administered intraperitonally. Enhancement of callus induction and cucurbitacin content. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while reducing blood glucose and improving lipid levels. Physiological effects of allelopathic activity of citrullus colocynthis on vicia faba and hordeum vulgare hediat m. The fruit of citrullus colocynthis has been studied extensively for its wide range of biological. Science and technology, general agricultural chemicals antimitotic agents antineoplastic agents fertilizers research food additives germination liquid chromatography phytochemicals plant. Screening of antioxidant potential of citrullus colocynthis methanolic extract sudhanshu 1, nidhi rao 1 sandhya mittal 1 and ekta menghani 2 1suresh gyan vihar university, jaipur 2mahatma gandhi institute of applied sciences, jecrc campus, jaipur22. Citrullus colocynthis fruits were extracted by different solvents nhexane. The bitter apple is a vinelike plant commonly found in asia and the mediterranean basin. Four ringa secocucurbitane triterpenoids, colocynthenins ad 14, together with seven known cucurbitane triterpenoids 511, were isolated from the fruits of citrullus colocynthis. Pdf the present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of. Cucurbitacins from the leaves of citrullus colocynthis l.
Effects of alkaloid rich extract of citrullus colocynthis fruits on artemia salina and human cancerous mcf7 and hepg2 cells aniruddha mukherjee, savita d patil abstract in the present research the anticancer effect of alkaloid rich extract of citrullus colocynthis fruits. The fruit pulp of colocynth has medicinal properties while the seeds. These compounds include elatermidine, glycosides, resin, dihydric alcohol, heltiacontane, citrullin and citrullinic acid. Files are available under licenses specified on their description page.
Germplasm of citrullus colocynthis in the united arab emirates was studied to find variation in it. Citrullus colocynthis cct, also known as bitter apple, wild gourd, tumba and wine of sodom, is known for its medicinal value since long. Department of agriculture agricultural research service. Attention as a natural insecticide and its activity has been evaluated against. Citrullus colocynthis, also known as bitter cucumber, is a fruitbearing plant sometimes used medicinally. Fifty rats were randomly divided into five groups 4 experimental and 1 controls. Cocyntal activated charcoal, citrullus colocynthis fruit, copper liquid out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Ibhrahim1 department of botany and microbiology, college of science, king saud university.
Citrullus colocynthis on integrated taxonomic information system. Citrullus colocynthis in the germplasm resources information network grin, u. It was banned by the food and drug administration fda in 1991. Taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Citrullus colocynthis as the cause of acute rectorrhagia. It was banned by the food and drug administration in 1991 taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Transesterification of citrullus colocynthis thumba oil. Citrullus colocynthis is a very droughttolerant medicinal species, closely related to watermelon c.
As already mentioned, that flour enriches and thickens soups as well as other foods. Al rabiah botany and microbiology department, faculty of science, king saud university, riyadh, saudi arabia. All structured data from the file and property namespaces is available under the creative commons cc0 license. The present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of extracts and chemicals identified from citrullus colocynthis. To evaluated the differential effects of ethanol extraction of citrullus colocynthis c. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Citrullus colocynthis extracts insecticidal activity pdf abstract.
Citrullus colocynthis fruits are usually recognized for its wide range of medicinal uses as well as pharmaceutical and nutraceutical potential. Citrullus colocynthis contained carbohydrate, protein, separated amino acid, tannins, saponins. Citrullus colocynthis, cucurbitaceae, indravaruni, bitter apple. Effects of hydroethanol extract of citrullus colocynthis. The effect of citrullus colocynthis extract on cutaneous. This research discussed an analytical study of citrullus colocynthis plants oil, where. Colocynthis homaccord fda prescribing information, side.
Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Colocynth definition of colocynth by the free dictionary. Effect of the rootknot nematode meloidogyne incognita and the fruit extract of citrullus colocynthis on chlorophyll content a, b and total mgg of fr. Screening of antioxidant potential of methanolic extract. Citrullus colocynthis in saudi arabia source migahid, 1996. Citrullus colocynthis, cucurbitacins, cytotoxicity. Twenty five different accessions of the species were collected. The leaf extract of two cucurbitacious plants citrullus colocynthis and cucurbita. The main clinical feature was acute rectorrhagia preceeded by mucosal diarrhea with tenesmus, which gradually progressed to bloody diarrhea and overt rectorrhagia within 3 to 4 hours. Citrullus colocynthis is a medicinal plant that has anticancer property mediated by apoptosis. Citrullus colocynthis fruits are usually recognized for its wide received in revised form range.
Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ecd calculations. Citrullus colocynthis extracts insecticidal activity pdf. Citrullus colocynthis an overview sciencedirect topics. Despite its promise for the food industry, it is the smallscale, subsistence use that most concerns us here. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. Sollmann t 1957 a manual of pharmacology and its applications to. Citrullus colocynthis supplement health benefits, dosage. Extraction and characterization of citrullus colocynthis oil. Cphydroxybenzoylglycoflavones from citrullus colocynthis. Effects of alkaloid rich extract of citrullus colocynthis. Chemical constituents and pharmacological effects of. Based on the above findings, the researchers agreed that citrullus colocynthis is suitable for use as an antiinflammatory agent. These plants have lemonsized fruits which are known for their medicinal properties. The present study focused on the cytotoxic and genotoxic potency of aqueous leaves extract of this plant.
Autecological studies on citrullus colocynthis species in saudi arabia najat a. Several studies on this plant reported and focused on the biological and toxicological profile of fruits pulp. Four patients with colocynth intoxication are presented. Autecological studies on citrullus colocynthis species in.
Persons familiar with the common watermelon vine need no description of the plant which produces colocynth apples. This page was last edited on 24 november 2014, at 11. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while. New state records for citrullus, cucumis, and cucurbita cucurbitaceae outside of cultivation in the usa. Schrad is a valuable cucurbit plant, widely distributed in the desert areas of the world. The present study was performed to determine the efficacy of citrullus colocynthis on cutaneous leishmaniasis lesion in human. Conventionally citrullus colocynthis fruits are used in antidiabetic treatment in mediterranean countries. Report by journal of the alabama academy of science. Previous studies in our laboratory showed that citrullus colocynthis pulp seedless extract. Citrullus colocynthis was reported in multiple ethnopharmacologic studies from different part of the world as a traditional remedy for a variety of diseases including gastrointestinal, musculoskeletal, neurological, cardiovascular, and respiratory disorders also, diabetes mellitus is known as the most popular traditional indication of c.
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